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Int. J. Mol. Sci. 2015, 16(6), 12119-12130; doi:10.3390/ijms160612119

Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell Cultures

Institute of Food Science Research (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, 28049 Madrid, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Paula Andrade
Received: 29 April 2015 / Revised: 21 May 2015 / Accepted: 21 May 2015 / Published: 27 May 2015
(This article belongs to the Special Issue Phenolics and Polyphenolics 2015)
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Abstract

Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI), although the mechanisms involved are not completely understood. In this paper, cranberry phenolic compounds and their potential microbial-derived metabolites (such as simple phenols and benzoic, phenylacetic and phenylpropionic acids) were tested for their capacity to inhibit the adherence of uropathogenic Escherichia coli (UPEC) ATCC®53503™ to T24 epithelial bladder cells. Catechol, benzoic acid, vanillic acid, phenylacetic acid and 3,4-dihydroxyphenylacetic acid showed anti-adhesive activity against UPEC in a concentration-dependent manner from 100–500 µM, whereas procyanidin A2, widely reported as an inhibitor of UPEC adherence on uroepithelium, was only statistically significant (p < 0.05) at 500 µM (51.3% inhibition). The results proved for the first time the anti-adhesive activity of some cranberry-derived phenolic metabolites against UPEC in vitro, suggesting that their presence in the urine could reduce bacterial colonization and progression of UTI. View Full-Text
Keywords: UPEC; uropathogenic Escherichia coli; UTI; urinary tract infection; T-24 cells; phenolic metabolites; flavan-3-ols UPEC; uropathogenic Escherichia coli; UTI; urinary tract infection; T-24 cells; phenolic metabolites; flavan-3-ols
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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González de Llano, D.; Esteban-Fernández, A.; Sánchez-Patán, F.; Martínlvarez, P.J.; Moreno-Arribas, M.V.; Bartolomé, B. Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell Cultures. Int. J. Mol. Sci. 2015, 16, 12119-12130.

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