Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters
AbstractFour new (1–4), along with six known (5–10) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The new compounds were structurally elucidated through spectroscopic analysis including UV (Ultraviolet Spectrum), IR (Infrared Spectrum), 1H-NMR (1Hydrogen-Nuclear Magnetic Resonance), 13C-NMR (13Carbon-Nuclear Magnetic Resonance), DEPT (Distortionless Enhancement by Polarization Transfer), 1H-1H COSY (1H-1H Correlation Spectroscopy), HSQC (Heteronuclear Single Quantum Coherence), HMBC (Heteronuclear Multiple Bond Correlation), NOESY (Nuclear Overhauser Enhancement Spectroscopy) and HR-MS (High Resolution Mass Specttrum) and their absolute configurations were proposed by comparison of NOESY spectra and specific optical rotations with those of known compounds and biosynthesis grounds. Compound 2 is the first sesquiterpene alkaloid isolated from this plant. New compounds 1–4 exhibited some cytotoxic activities against NB4, MKN-45 and MCF-7 cells at 20 μM and of which 4 showed the highest activity against NB4 and MKN-45 cells with inhibition rates of 85.6% and 30.5%, respectively. View Full-Text
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Gao, Z.-F.; Zhou, B.-H.; Zhao, J.-Y.; Cao, F.-J.; Zhou, L.; Geng, H.-L. Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters. Int. J. Mol. Sci. 2015, 16, 9119-9133.
Gao Z-F, Zhou B-H, Zhao J-Y, Cao F-J, Zhou L, Geng H-L. Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters. International Journal of Molecular Sciences. 2015; 16(5):9119-9133.Chicago/Turabian Style
Gao, Zhao-Feng; Zhou, Bo-Hang; Zhao, Jie-Yu; Cao, Fang-Jun; Zhou, Le; Geng, Hui-Ling. 2015. "Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters." Int. J. Mol. Sci. 16, no. 5: 9119-9133.