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Int. J. Mol. Sci. 2015, 16(5), 9119-9133; doi:10.3390/ijms16059119

Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters

College of Science, Northwest A&F University, Yangling 712100, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 16 March 2015 / Revised: 14 April 2015 / Accepted: 15 April 2015 / Published: 23 April 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Four new (14), along with six known (510) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The new compounds were structurally elucidated through spectroscopic analysis including UV (Ultraviolet Spectrum), IR (Infrared Spectrum), 1H-NMR (1Hydrogen-Nuclear Magnetic Resonance), 13C-NMR (13Carbon-Nuclear Magnetic Resonance), DEPT (Distortionless Enhancement by Polarization Transfer), 1H-1H COSY (1H-1H Correlation Spectroscopy), HSQC (Heteronuclear Single Quantum Coherence), HMBC (Heteronuclear Multiple Bond Correlation), NOESY (Nuclear Overhauser Enhancement Spectroscopy) and HR-MS (High Resolution Mass Specttrum) and their absolute configurations were proposed by comparison of NOESY spectra and specific optical rotations with those of known compounds and biosynthesis grounds. Compound 2 is the first sesquiterpene alkaloid isolated from this plant. New compounds 14 exhibited some cytotoxic activities against NB4, MKN-45 and MCF-7 cells at 20 μM and of which 4 showed the highest activity against NB4 and MKN-45 cells with inhibition rates of 85.6% and 30.5%, respectively. View Full-Text
Keywords: dihydro-β-agarofuran; sesquiterpene; Parnassia wightiana; sesquiterpene alkaloid dihydro-β-agarofuran; sesquiterpene; Parnassia wightiana; sesquiterpene alkaloid
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MDPI and ACS Style

Gao, Z.-F.; Zhou, B.-H.; Zhao, J.-Y.; Cao, F.-J.; Zhou, L.; Geng, H.-L. Further Study on Chemical Constituents of Parnassia wightiana Wall: Four New Dihydro-β-agarofuran Sesquiterpene Polyesters. Int. J. Mol. Sci. 2015, 16, 9119-9133.

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