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Int. J. Mol. Sci. 2015, 16(5), 11648-11658; doi:10.3390/ijms160511648

The Influence of PSCA Gene Variation on Its Expression and Gastric Adenocarcinoma Susceptibility in the Northwest Chinese Population

1
State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China
2
Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
3
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
4
Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Research Institute of Translation Medicine, Shanghai Jiao Tong University, Shanghai 200240, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 30 March 2015 / Revised: 4 May 2015 / Accepted: 11 May 2015 / Published: 21 May 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
View Full-Text   |   Download PDF [2427 KB, uploaded 21 May 2015]   |  

Abstract

Gastric adenocarcinoma (GAC) imposes a considerable health burden around the world. Gene variation in prostate stem cell antigen gene (PSCA) has been identified to be associated with GAC risk, while the results showed regional variation. To explore the influence of PSCA gene variation on its expression and GAC risk in the Northwest Chinese population, four single nucleotide polymorphisms (SNPs) of PSCA were genotyped in 476 GAC cases and 481 controls using MassARRAY system. Two SNPs of rs2294008 (C>T) and rs2976392 (G>A) were identified to be associated with GAC risk. rs2294008, rs2976392 and rs10216533 made up two statistically significant haplotypes (Hap-CGG and Hap-TAG). Additionally, PSCA expression was analyzed by quantitative real time PCR, immunohistochemistry and tissue microarray. The results showed that PSCA expression was decreased in GAC tissues compared with adjacent normal tissues. For normal tissues, PSCA expression was higher with Hap-TA than that with Hap-CG. For GAC tissues, the differentiation degree of Hap-TA was higher than that of Hap-CG. The expression distribution of PSCA in multiple human organs showed disparity. These results suggest that PSCA gene variation has a potential effect on its expression and GAC risk in the Northwest Chinese population. View Full-Text
Keywords: prostate stem cell antigen (PSCA); gastric adenocarcinoma; single nucleotide polymorphism (SNP); haplotype; gene expression prostate stem cell antigen (PSCA); gastric adenocarcinoma; single nucleotide polymorphism (SNP); haplotype; gene expression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, W.; Liang, P.; Wang, W.; Dai, P.; Wang, Q.; Yan, W.; Zhao, J.; Sun, J.; Peng, Y.; Cui, D.; Yan, Z. The Influence of PSCA Gene Variation on Its Expression and Gastric Adenocarcinoma Susceptibility in the Northwest Chinese Population. Int. J. Mol. Sci. 2015, 16, 11648-11658.

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