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Int. J. Mol. Sci. 2015, 16(5), 10324-10336; doi:10.3390/ijms160510324

Cell Adhesion and in Vivo Osseointegration of Sandblasted/Acid Etched/Anodized Dental Implants

1
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Korea
2
Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea
3
Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Korea
4
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 25 March 2015 / Revised: 8 April 2015 / Accepted: 29 April 2015 / Published: 6 May 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
View Full-Text   |   Download PDF [7861 KB, uploaded 6 May 2015]   |  

Abstract

The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics in vivo. Four different types of Ti implants were examined, that is, machined Ti (control), SLA, anodized, and Modi-ANO Ti. In the cell adhesion study, Modi-ANO Ti showed higher initial MG-63 cell adhesion and induced greater filopodia growth than other groups. In vivo study in a beagle model revealed the bone-to-implant contact (BIC) of Modi-ANO Ti (74.20% ± 10.89%) was much greater than those of machined (33.58% ± 8.63%), SLA (58.47% ± 12.89), or ANO Ti (59.62% ± 18.30%). In conclusion, this study demonstrates that Modi-ANO Ti implants produced by sandblasting, acid etching, and anodizing improve cell adhesion and bone ongrowth as compared with machined, SLA, or ANO Ti implants. These findings suggest that the application of Modi-ANO surface treatment could improve the osseointegration of dental implant. View Full-Text
Keywords: titanium implant; sandblasting and acid etching; anodization; osteoblast; osseointegration titanium implant; sandblasting and acid etching; anodization; osteoblast; osseointegration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, M.-H.; Park, K.; Choi, K.-H.; Kim, S.-H.; Kim, S.E.; Jeong, C.-M.; Huh, J.-B. Cell Adhesion and in Vivo Osseointegration of Sandblasted/Acid Etched/Anodized Dental Implants. Int. J. Mol. Sci. 2015, 16, 10324-10336.

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