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Int. J. Mol. Sci. 2015, 16(5), 10095-10104; doi:10.3390/ijms160510095

Histomorphometric Evaluation of the Small Coronary Arteries in Rats Exposed to Industrial Noise

1
Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute, 2829-511 Monte de Caparica, Portugal
2
Department of Anatomy, Abel Salazar Biomedical Sciences Institute, University of Porto, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Francis J. Miller
Received: 30 January 2015 / Revised: 2 April 2015 / Accepted: 14 April 2015 / Published: 4 May 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [739 KB, uploaded 4 May 2015]   |  

Abstract

Morphological changes induced by industrial noise (IN) have been experimentally observed in several organs. Histological observations of the coronary arteries showed prominent perivascular tissue and fibrosis among IN-exposed rats. The effects on the small arteries are unknown. Objective: To evaluate the histomorphometric changes induced by IN on rat heart small arteries. Methods: Twenty Wistar rats exposed to IN during a maximum period of seven months and 20 age-matched controls were studied. Hearts were transversely sectioned from ventricular apex to atria and a mid-ventricular fragment was selected for analysis. The histological images were obtained with an optical microscope using 400× magnifications. A total of 634 arterial vessels (298 IN-exposed and 336 controls) were selected. The mean lumen-to-vessel wall (L/W) and mean vessel wall-to-perivascular tissue (W/P) ratios were calculated using image J software. Results: There were no differences between exposed and control animals in their L/W ratios (p = 0.687) and time variations in this ratio were non-significant (p = 0.110). In contrast, exposed animals showed lower W/P ratios than control animals (p < 0.001), with significant time variations (p = 0.004). Conclusions: Industrial noise induced an increase in the perivascular tissue of rat small coronary arteries, with significant development of periarterial fibrosis. View Full-Text
Keywords: industrial noise; small coronary arteries; low-frequency noise industrial noise; small coronary arteries; low-frequency noise
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lousinha, A.; Antunes, E.; Borrecho, G.; Oliveira, M.J.; Brito, J.; Santos, J.M. Histomorphometric Evaluation of the Small Coronary Arteries in Rats Exposed to Industrial Noise. Int. J. Mol. Sci. 2015, 16, 10095-10104.

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