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Int. J. Mol. Sci. 2015, 16(4), 7802-7838; doi:10.3390/ijms16047802

Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease

1
Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, Australia
2
School of Pharmacy and Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, Australia
3
Royal Botanic Gardens Melbourne, South Yarra, VIC 3141, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Patricia Berninsone
Received: 5 February 2015 / Revised: 16 March 2015 / Accepted: 19 March 2015 / Published: 8 April 2015
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
View Full-Text   |   Download PDF [2338 KB, uploaded 8 April 2015]

Abstract

Lectins are non-immunoglobulin proteins that bind diverse sugar structures with a high degree of selectivity. Lectins play crucial role in various biological processes such as cellular signaling, scavenging of glycoproteins from the circulatory system, cell–cell interactions in the immune system, differentiation and protein targeting to cellular compartments, as well as in host defence mechanisms, inflammation, and cancer. Among all the sources of lectins, plants have been most extensively studied. However, more recently fungal lectins have attracted considerable attention due to their antitumor, antiproliferative and immunomodulatory activities. Given that only 10% of mushroom species are known and have been taxonomically classified, mushrooms represent an enormous unexplored source of potentially useful and novel lectins. In this review we provide an up-to-date summary on the biochemical, molecular and structural properties of mushroom lectins, as well as their versatile applications specifically focusing on mushroom lectin bioactivity. View Full-Text
Keywords: lectins; mushrooms; bioactivity; structure; antiproliferative activity; immunomodulatory activity; antiviral activity lectins; mushrooms; bioactivity; structure; antiproliferative activity; immunomodulatory activity; antiviral activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hassan, M.A.A.; Rouf, R.; Tiralongo, E.; May, T.W.; Tiralongo, J. Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease. Int. J. Mol. Sci. 2015, 16, 7802-7838.

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