Next Article in Journal
Expression of S100A6 in Rat Hippocampus after Traumatic Brain Injury Due to Lateral Head Acceleration
Next Article in Special Issue
Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease
Previous Article in Journal
Cadmium Toxicity Induced Alterations in the Root Proteome of Green Gram in Contrasting Response towards Iron Supplement
Previous Article in Special Issue
P-Glycoprotein and Drug Resistance in Systemic Autoimmune Diseases
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(4), 6356-6377; doi:10.3390/ijms15046356

Importance of N-Glycosylation on CD147 for Its Biological Functions

Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 9 December 2013 / Revised: 25 February 2014 / Accepted: 4 April 2014 / Published: 15 April 2014
(This article belongs to the Special Issue Glycosylation and Glycoproteins)
View Full-Text   |   Download PDF [656 KB, uploaded 19 June 2014]   |  

Abstract

Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation. View Full-Text
Keywords: CD147; N-glycosylation; glycosyltransferases; matrix metalloproteinase; cancer invasion and metastasis CD147; N-glycosylation; glycosyltransferases; matrix metalloproteinase; cancer invasion and metastasis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bai, Y.; Huang, W.; Ma, L.-T.; Jiang, J.-L.; Chen, Z.-N. Importance of N-Glycosylation on CD147 for Its Biological Functions. Int. J. Mol. Sci. 2014, 15, 6356-6377.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top