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Int. J. Mol. Sci. 2015, 16(4), 6677-6693; doi:10.3390/ijms16046677

Long Noncoding RNA MALAT-1 Enhances Stem Cell-Like Phenotypes in Pancreatic Cancer Cells

1,2,†
,
1,2,†
,
1,2,†
,
3
,
1,2
,
2
,
2
and
1,2,*
1
Department of Medical Oncology and Pancreatic Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
2
Shanghai Key Laboratory of Pancreatic Diseases, Shanghai 201620, China
3
Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
Current Address: GEOMAR Helmholtz Centre for Ocean Research Kiel, Marine Natural Products Chemistry, Am Kiel-Kanal 44, Kiel 24106, Germany.
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 13 January 2015 / Revised: 20 February 2015 / Accepted: 20 February 2015 / Published: 24 March 2015
(This article belongs to the Special Issue Pre-mRNA Splicing 2015)
View Full-Text   |   Download PDF [2945 KB, uploaded 24 March 2015]   |  

Abstract

Cancer stem cells (CSCs) play a vital role in tumor initiation, progression, metastasis, chemoresistance, and recurrence. The mechanisms that maintain the stemness of these cells remain largely unknown. Our previous study indicated that MALAT-1 may serve as an oncogenic long noncoding RNA in pancreatic cancer by promoting epithelial-mesenchymal transition (EMT) and regulating CSCs markers expression. More significantly, there is emerging evidence that the EMT process may give rise to CSCs, or at least cells with stem cell-like properties. Therefore, we hypothesized that MALAT-1 might enhance stem cell-like phenotypes in pancreatic cancer cells. In this study, our data showed that MALAT-1 could increase the proportion of pancreatic CSCs, maintain self-renewing capacity, decrease the chemosensitivity to anticancer drugs, and accelerate tumor angiogenesis in vitro. In addition, subcutaneous nude mouse xenografts revealed that MALAT-1 could promote tumorigenicity of pancreatic cancer cells in vivo. The underlying mechanisms may involve in increased expression of self-renewal related factors Sox2. Collectively, we for the first time found the potential effects of MALAT-1 on the stem cell-like phenotypes in pancreatic cancer cells, suggesting a novel role of MALAT-1 in tumor stemness, which remains to be fully elucidated. View Full-Text
Keywords: MALAT-1; stemness; long noncoding RNA; cancer stem cells MALAT-1; stemness; long noncoding RNA; cancer stem cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jiao, F.; Hu, H.; Han, T.; Yuan, C.; Wang, L.; Jin, Z.; Guo, Z.; Wang, L. Long Noncoding RNA MALAT-1 Enhances Stem Cell-Like Phenotypes in Pancreatic Cancer Cells. Int. J. Mol. Sci. 2015, 16, 6677-6693.

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