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Int. J. Mol. Sci. 2015, 16(3), 5682-5696; doi:10.3390/ijms16035682

Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing

State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, Shenzhen Institute of Research and Innovation, The University of Hong Kong, L8-43, 21 Sassoon Road, Pokfulam, Hong Kong, China
Author to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 23 December 2014 / Revised: 28 February 2015 / Accepted: 4 March 2015 / Published: 11 March 2015
(This article belongs to the Special Issue Pre-mRNA Splicing 2015)
View Full-Text   |   Download PDF [1689 KB, uploaded 11 March 2015]   |  


A processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression. View Full-Text
Keywords: pre-mRNA splicing; RNA surveillance; exosome; microRNA processing; mirtron; circular RNA pre-mRNA splicing; RNA surveillance; exosome; microRNA processing; mirtron; circular RNA

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pan, K.; Lee, J.T.H.; Huang, Z.; Wong, C.-M. Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing. Int. J. Mol. Sci. 2015, 16, 5682-5696.

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