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Int. J. Mol. Sci. 2015, 16(3), 6298-6311; doi:10.3390/ijms16036298

Genotyping Test with Clinical Factors: Better Management of Acute Postoperative Pain?

1
Laboratoire de Pharmacologie, Pharmacie Clinique et Contrôle de Qualité des Médicaments, Faculté de Pharmacie, Saint-Joseph University of Beirut, B.P. 11-5076-Riad El Solh, Beirut 1107 2180, Lebanon
2
Université Paris Descartes, Unité INSERM UMR-S 1144, Paris F-75006, France
3
Department of Anesthesia and Critical Care, Hôtel-Dieu de France Hospital-Saint-Joseph University of Beirut, B.P. 16-6830, Beirut 1100 2160, Lebanon
*
Author to whom correspondence should be addressed.
Academic Editor: Sabrina Angelini
Received: 12 January 2015 / Revised: 12 February 2015 / Accepted: 2 March 2015 / Published: 19 March 2015
(This article belongs to the Special Issue Pharmacogenetics and Personalized Medicine)
View Full-Text   |   Download PDF [762 KB, uploaded 19 March 2015]   |  

Abstract

Individualization of acute postoperative pain treatment on an evidence-based decision process is a major health concern. The aim of this study is to investigate the influence of genetic and non-genetic factors on the variability of response to morphine in acute postoperative pain. A group of nighty-five patients undergoing major surgery were included prospectively. At 24 h, a logistic regression model was carried out to determine the factors associated with morphine doses given by a Patient Controlled Analgesia device. The dose of morphine was associated with age (p = 0.011), patient weight (p = 0.025) and the duration of operation (p = 0.030). This dose decreased with patient’s age and duration of operation and increased with patient’s weight. OPRM1 and ABCB1 polymorphisms were significantly associated with administered dose of morphine (p = 0.038 and 0.012 respectively). Patients with at least one G allele for c.118A>G OPRM1 polymorphism (AG/GG) needed 4 times the dose of morphine of AA patients. Additionally, patients with ABCB1 CT and CC genotypes for c.3435C>T polymorphism were 5.6 to 7.1 times more prone to receive higher dose of morphine than TT patients. Our preliminary results support the evidence that OPRM1/ABCB1 genotypes along with age, weight and duration of operation have an impact on morphine consumption for acute postoperative pain treatment. View Full-Text
Keywords: morphine; polymorphism; OPRM1; ABCB1; pain; pharmacogenetics morphine; polymorphism; OPRM1; ABCB1; pain; pharmacogenetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hajj, A.; Peoc'h, K.; Laplanche, J.-L.; Jabbour, H.; Naccache, N.; Zeid, H.A.; Yazbeck, P.; Khabbaz, L.R. Genotyping Test with Clinical Factors: Better Management of Acute Postoperative Pain? Int. J. Mol. Sci. 2015, 16, 6298-6311.

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