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Int. J. Mol. Sci. 2015, 16(3), 5510-5516; doi:10.3390/ijms16035510

Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women

1
Department of Medical Sciences, Section of Microbiology and Genetics, University of Ferrara, 44100 Ferrara, Italy
2
Department of Morphology, Surgery and Experimental Medicine, Section of Gynecology and Obstetrics, University of Ferrara, 44100 Ferrara, Italy
3
University Hospital "S. Anna", 44100 Ferrara, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Robert J. Norman
Received: 11 December 2014 / Revised: 17 February 2015 / Accepted: 4 March 2015 / Published: 10 March 2015
(This article belongs to the Special Issue Advances in Reproductive Biology)
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Abstract

The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56+KIR2DL4+ (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56+KIR2DL4+ (e)NK cell percentages. View Full-Text
Keywords: primary infertility; secondary infertility; soluble human leukocyte antigen (sHLA-G); uterine flushing; endometrial natural killer; CD158d (KIR2DL4) primary infertility; secondary infertility; soluble human leukocyte antigen (sHLA-G); uterine flushing; endometrial natural killer; CD158d (KIR2DL4)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rizzo, R.; Lo Monte, G.; Bortolotti, D.; Graziano, A.; Gentili, V.; Di Luca, D.; Marci, R. Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women. Int. J. Mol. Sci. 2015, 16, 5510-5516.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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