Next Article in Journal
The 15q11.2 BP1–BP2 Microdeletion Syndrome: A Review
Next Article in Special Issue
Decellularized Human Skeletal Muscle as Biologic Scaffold for Reconstructive Surgery
Previous Article in Journal
Functional Properties of the Catalytic Domain of Mouse Acidic Mammalian Chitinase Expressed in Escherichia coli
Previous Article in Special Issue
Running Exercise Alleviates Pain and Promotes Cell Proliferation in a Rat Model of Intervertebral Disc Degeneration
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(2), 4043-4067; doi:10.3390/ijms16024043

Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine

Department of Histology and Embryology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 50038, Czech Republic
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Francesc Cebrià
Received: 29 December 2014 / Revised: 27 January 2015 / Accepted: 2 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
View Full-Text   |   Download PDF [764 KB, uploaded 13 February 2015]   |  

Abstract

Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the field of stem cell research. The complications related to the usage of pluripotent embryonic stem cells (ESCs) in human medicine, particularly ESC isolation and histoincompatibility were bypassed with induced pluripotent stem cell (iPSC) technology. The human iPSCs can be used for studying embryogenesis, disease modeling, drug testing and regenerative medicine. iPSCs can be diverted to different cell lineages using small molecules and growth factors. In this review we have focused on iPSC differentiation towards cardiac and neuronal lineages. Moreover, we deal with the use of iPSCs in regenerative medicine and modeling diseases like myocardial infarction, Timothy syndrome, dilated cardiomyopathy, Parkinson’s, Alzheimer’s and Huntington’s disease. Despite the promising potential of iPSCs, genome contamination and low efficacy of cell reprogramming remain significant challenges. View Full-Text
Keywords: iPS cells; cell reprogramming; directed differentiation; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease iPS cells; cell reprogramming; directed differentiation; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Skalova, S.; Svadlakova, T.; Qureshi, W.M.S.; Dev, K.; Mokry, J. Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine. Int. J. Mol. Sci. 2015, 16, 4043-4067.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top