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Int. J. Mol. Sci. 2015, 16(2), 3757-3768; doi:10.3390/ijms16023757

The Role of hOGG1 C1245G Polymorphism in the Susceptibility to Lupus Nephritis and Modulation of the Plasma 8-OHdG in Patients with Systemic Lupus Erythematosus

1,2,3,4
,
1,2,5
,
3,4,6
,
1,2,7,* and 1,2,3,8,*
1
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
2
Faculty of Medicine, National Yang-Ming University, Taipei 112, Taiwan
3
Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan
4
Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan
5
Division of Thoracic Surgery, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242, Taiwan
6
Mackay Junior College of Medicine, Nursing, and Management, New Taipei City 252, Taiwan
7
Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
8
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
A portion of the data, the plasma levels of 8-OHdG, has been published in the scientific journal “Clinical & Experimental Immunology (CEI)”.
*
Authors to whom correspondence should be addressed.
Academic Editors: Chak-Sing Lau and Vera Sau-Fong Chan
Received: 26 November 2014 / Accepted: 29 January 2015 / Published: 9 February 2015
View Full-Text   |   Download PDF [928 KB, uploaded 9 February 2015]   |  

Abstract

We investigated whether the C1245G polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) gene confers the susceptibility to systemic lupus erythematosus (SLE) occurrence of lupus nephritis and affects the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with SLE. A total of 45 healthy controls and 85 SLE patients were recruited. The C1245G polymorphism of the hOGG1 gene was determined by direct sequencing. The frequency of occurrence of the hOGG1 1245 GG genotype in SLE patients was 31.8% (27/85), which is lower than that of healthy controls of 53.3% (24/45). Thirty-three (33/85, 38.8%) SLE patients developed lupus nephritis. Significantly, SLE patients harboring the hOGG1 1245 GG genotype had a higher incidence to develop lupus nephritis than did those harboring the hOGG1 1245 CC or CG genotype (15/27, 55.6% vs.18/58, 31.0%, p = 0.031). Divided into subgroups, SLE patients harboring the hOGG1 1245 GG genotype had the highest plasma levels of 8-OHdG among patients with all genotypes, with regard to the coexistence of lupus nephritis (p = 0.020, ANOVA), including those with nephritis harboring the hOGG1 1245 CC or CG genotypes (p = 0.037), those without nephritis harboring the hOGG1 1245 GG genotype (p = 0.050), and those without nephritis harboring the hOGG1 1245 CC or CG genotype (p = 0.054). We conclude that the C1245G polymorphism of hOGG1 may be one of the factors that confer the susceptibility to lupus nephritis and modulate the plasma level of 8-OHdG in patients with SLE. View Full-Text
Keywords: 8-hydroxy-2'-deoxyguanosine (8-OHdG); human 8-oxoguanine glycosylase 1 (hOGG1) C1245G polymorphism; lupus nephritis; systemic lupus erythematosus (SLE) 8-hydroxy-2'-deoxyguanosine (8-OHdG); human 8-oxoguanine glycosylase 1 (hOGG1) C1245G polymorphism; lupus nephritis; systemic lupus erythematosus (SLE)
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MDPI and ACS Style

Lee, H.-T.; Lin, C.-S.; Lee, C.-S.; Tsai, C.-Y.; Wei, Y.-H. The Role of hOGG1 C1245G Polymorphism in the Susceptibility to Lupus Nephritis and Modulation of the Plasma 8-OHdG in Patients with Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2015, 16, 3757-3768.

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