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Int. J. Mol. Sci. 2015, 16(2), 3434-3440; doi:10.3390/ijms16023434

Current Status of Photodynamic Therapy in Digestive Tract Carcinoma in Japan

Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki 852-8501, Japan
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Received: 15 December 2014 / Revised: 15 January 2015 / Accepted: 30 January 2015 / Published: 4 February 2015
(This article belongs to the Special Issue Advances in Photodynamic Therapy)
View Full-Text   |   Download PDF [622 KB, uploaded 4 February 2015]

Abstract

Photodynamic therapy (PDT) is an effective local treatment modality as a cancer-specific laser ablation in malignancy of some organs including digestive tracts or bile duct. In Japan, PDT has been applied at the early period after the first clinical induction in 1980’s. Although the useful efficacy was clarified, PDT has not been fully applied because of the phototoxicity of the porfimer sodium. The next generated talaporfin-sodium was used for PDT, in which phototoxicity was reduced and, however, the clinical efficacy for digestive tract malignancy has not yet been clarified. By proceeding the experimental and clinical trials, it is necessary to clarify the evidence of efficacy as a local powerful treatment with the conventional surgery, brachiotherapy and chemotherapy in the future step. View Full-Text
Keywords: photodynamic therapy; digestive tract cancer; bile duct carcinoma; porfimer sodium; talaporfin sodium; Japan photodynamic therapy; digestive tract cancer; bile duct carcinoma; porfimer sodium; talaporfin sodium; Japan
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nanashima, A.; Nagayasu, T. Current Status of Photodynamic Therapy in Digestive Tract Carcinoma in Japan. Int. J. Mol. Sci. 2015, 16, 3434-3440.

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