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Int. J. Mol. Sci. 2015, 16(2), 3441-3451; doi:10.3390/ijms16023441

Synthesis of a Temperature-Sensitive Matrine-Imprinted Polymer and Its Potential Application for the Selective Extraction of Matrine from Radix Sophorae Tonkinensis

1
School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, China
2
School of Pharmaceutical, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jurriaan Huskens
Received: 23 November 2014 / Revised: 19 January 2015 / Accepted: 26 January 2015 / Published: 4 February 2015
(This article belongs to the Section Molecular Recognition)
View Full-Text   |   Download PDF [2934 KB, uploaded 4 February 2015]   |  

Abstract

A temperature-sensitive matrine-imprinted polymer was prepared in chloroform by free-radical cross-linking copolymerization of methacrylic acid at 60 °C in the presence of ethylene glycol dimethacrylate as the cross-linker, N-isopropyl acrylamide as the temperature-responsive monomer and matrine as the template molecule. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on molecular imprinted polymer (MIP) at 50 °C. Additionally, the thermoresponsive MIP was tested for its application as a sorbent material for the selective separation of matrine from Chinese medicinal plant radix Sophorae tonkinensis. It was shown that the thermoresponsive MIP displayed different efficiency in clean-up and enrichments using the SPE protocol at different temperatures. View Full-Text
Keywords: molecularly imprinted polymer; N-isopropyl acrylamide; matrine; ultrasonic extraction molecularly imprinted polymer; N-isopropyl acrylamide; matrine; ultrasonic extraction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jiang, M.; Wang, L.; Liu, X.; Yang, H.; Ren, F.; Gan, L.; Jiang, W. Synthesis of a Temperature-Sensitive Matrine-Imprinted Polymer and Its Potential Application for the Selective Extraction of Matrine from Radix Sophorae Tonkinensis. Int. J. Mol. Sci. 2015, 16, 3441-3451.

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