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Int. J. Mol. Sci. 2015, 16(12), 29843-29855; doi:10.3390/ijms161226204

Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania
2
Laboratory of General Biochemistry and Physical Pharmacy, Centre for Nano- and Biophotonics, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium
3
Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, Ghent 9000, Belgium
4
Department of Microbiology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iasi, 16 University Street, Iasi 700115, Romania
5
Department of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi 700487, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Received: 2 August 2015 / Revised: 1 December 2015 / Accepted: 2 December 2015 / Published: 15 December 2015
(This article belongs to the Special Issue Chitins 2015)
View Full-Text   |   Download PDF [3481 KB, uploaded 15 December 2015]   |  

Abstract

The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity. View Full-Text
Keywords: sulfonamide-chitosan derivatives; film; swelling ratio; biodegradation; antioxidant effects sulfonamide-chitosan derivatives; film; swelling ratio; biodegradation; antioxidant effects
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dragostin, O.M.; Samal, S.K.; Lupascu, F.; Pânzariu, A.; Dubruel, P.; Lupascu, D.; Tuchilus, C.; Vasile, C.; Profire, L. Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing. Int. J. Mol. Sci. 2015, 16, 29843-29855.

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