Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing
AbstractThe objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order to enhance the biological effects of chitosan. The morphology and physical properties of functionalized chitosan films as well the antioxidant effects of sulfonamide-chitosan derivatives were investigated. The chitosan-derivative films showed a rough surface and hydrophilic properties, which are very important features for their use as a wound dressing. The film based on chitosan-sulfisoxazol (CS-S6) showed the highest swelling ratio (197%) and the highest biodegradation rate (63.04%) in comparison to chitosan film for which the swelling ratio was 190% and biodegradation rate was only 10%. Referring to the antioxidant effects the most active was chitosan-sulfamerazine (CS-S5) which was 8.3 times more active than chitosan related to DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging ability. This compound showed also a good ferric reducing power and improved total antioxidant capacity. View Full-Text
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Dragostin, O.M.; Samal, S.K.; Lupascu, F.; Pânzariu, A.; Dubruel, P.; Lupascu, D.; Tuchilus, C.; Vasile, C.; Profire, L. Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing. Int. J. Mol. Sci. 2015, 16, 29843-29855.
Dragostin OM, Samal SK, Lupascu F, Pânzariu A, Dubruel P, Lupascu D, Tuchilus C, Vasile C, Profire L. Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing. International Journal of Molecular Sciences. 2015; 16(12):29843-29855.Chicago/Turabian Style
Dragostin, Oana M.; Samal, Sangram K.; Lupascu, Florentina; Pânzariu, Andreea; Dubruel, Peter; Lupascu, Dan; Tuchilus, Cristina; Vasile, Cornelia; Profire, Lenuta. 2015. "Development and Characterization of Novel Films Based on Sulfonamide-Chitosan Derivatives for Potential Wound Dressing." Int. J. Mol. Sci. 16, no. 12: 29843-29855.