Next Article in Journal
The Historical Development of Immunoendocrine Concepts of Psychiatric Disorders and Their Therapy
Previous Article in Journal
Possible Mechanisms of Di(2-ethylhexyl) Phthalate-Induced MMP-2 and MMP-9 Expression in A7r5 Rat Vascular Smooth Muscle Cells
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(12), 28812-28840; doi:10.3390/ijms161226132

Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines—Flos Lonicerae Japonicae—Fructus Forsythiae Herb Couples as an Example

1,2,3,4
,
1,5
,
4
,
4
and
1,2,3,4,*
1
College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China
3
Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nanjing 210023, China
4
Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China
5
Nanjing Haichang Chinese Medicine Group Co., Ltd., Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 21 October 2015 / Revised: 21 November 2015 / Accepted: 24 November 2015 / Published: 4 December 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2547 KB, uploaded 4 December 2015]   |  

Abstract

Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative. View Full-Text
Keywords: bio-pharmaceutics of TCMs preparations; active constitutes identification; evaluation system of bioavailability; pharmaceutical technologies; absorption enhancer bio-pharmaceutics of TCMs preparations; active constitutes identification; evaluation system of bioavailability; pharmaceutical technologies; absorption enhancer
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhou, W.; Cai, B.; Shan, J.; Wang, S.; Di, L. Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines—Flos Lonicerae Japonicae—Fructus Forsythiae Herb Couples as an Example. Int. J. Mol. Sci. 2015, 16, 28812-28840.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top