Next Article in Journal
Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors
Next Article in Special Issue
Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects
Previous Article in Journal
DAG/PKCδ and IP3/Ca2+/CaMK IIβ Operate in Parallel to Each Other in PLCγ1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway
Previous Article in Special Issue
Application of Wnt Pathway Inhibitor Delivering Scaffold for Inhibiting Fibrosis in Urethra Strictures: In Vitro and in Vivo Study
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(12), 28523-28533; doi:10.3390/ijms161226112

Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats

1
Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea
2
School of Dentistry, Pusan National University, YangSan 676-870, Korea
3
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 31 July 2015 / Revised: 27 October 2015 / Accepted: 20 November 2015 / Published: 1 December 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
View Full-Text   |   Download PDF [3363 KB, uploaded 1 December 2015]   |  

Abstract

This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (n = 10 in each group). The site of cranial subcutaneous injection was the mid-point of the interpupillary line, and the site of intraoral submucosal injection was the ridge crest 2 mm below the cervical line of the mandibular left incisor. Before and immediately after filler injection, intraoral photos and lateral cephalometric radiographs were taken for analysis and comparison of the effect of the filler on the injection sites. The filler injected areas were converted into sequential size changes (%) of the baseline. Histomorphologic examination was performed after 12 weeks. The smallest value in the filler injected area was observed during the experimental period in the normal saline group (p < 0.001), which was almost absorbed at 4 weeks (7.19% ± 12.72%). The HA group exhibited a steady decrease in sequential size and showed a lower value than the DiHM and PDiHM groups (saline < HA < DHiM, PDHiM, p < 0.001). DiHM and PDiHM tended to increase for the first 4 weeks and later decreased until 12 weeks. In this study on DiHM and PDiHM, there was no histological abnormality in cranial skin and oral mucosa. DiHM and PDiHM filler materials with injection system provide an excellent alternative surgical method for use in oral and craniofacial fields. View Full-Text
Keywords: biocompatibility; efficacy; PMMA; hydroxypropyl methylcellulose; hyaluronic acid; filler; oral submucosa; cranial subcutaneous; rat biocompatibility; efficacy; PMMA; hydroxypropyl methylcellulose; hyaluronic acid; filler; oral submucosa; cranial subcutaneous; rat
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huh, J.-B.; Kim, J.-H.; Kim, S.; Lee, S.-H.; Shim, K.M.; Kim, S.E.; Kang, S.S.; Jeong, C.-M. Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats. Int. J. Mol. Sci. 2015, 16, 28523-28533.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top