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Int. J. Mol. Sci. 2015, 16(12), 28180-28193; doi:10.3390/ijms161226093

Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ

Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
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Academic Editor: Julian Borejdo
Received: 21 September 2015 / Revised: 16 November 2015 / Accepted: 18 November 2015 / Published: 26 November 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The uncontrolled migration of vascular smooth muscle cells (VSMCs) into the intima is a critical process in the development of atherosclerosis. Evodiamine, an indole alkaloid extracted from the Chinese medicine evodia, has been shown to inhibit tumor cell invasion and protect the cardiovascular system, but its effects on VSMCs remain unknown. In the present study, we investigated the inhibitory effects of evodiamine on the platelet-derived growth factor-BB (PDGF-BB)-induced VSMC migration using wound healing and transwell assays, and assessed its role in decreasing the protein levels of matrix metalloproteinases and cell adhesion molecules. More importantly, we found that evodiamine activated the expression and nuclear translocation of peroxisome proliferator-activated receptor γ (PPARγ). Inhibition of PPARγ activity by using its antagonist T0070907 and its specific siRNA oligonucleotides significantly attenuated the inhibitory effects of evodiamine on VSMC migration. Taken together, our results indicate a promising anti-atherogenic effect of evodiamine through attenuation of VSMC migration by activating PPARγ. View Full-Text
Keywords: evodiamine; vascular smooth muscle cells; migration; peroxisome proliferator-activated receptor γ evodiamine; vascular smooth muscle cells; migration; peroxisome proliferator-activated receptor γ
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ge, X.; Chen, S.; Liu, M.; Liang, T.; Liu, C. Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ. Int. J. Mol. Sci. 2015, 16, 28180-28193.

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