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Int. J. Mol. Sci. 2015, 16(12), 30075-30090; doi:10.3390/ijms161226210

Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond

1
The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA
2
Neurotoxicology Laboratory, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Antonio Segura-Carretero and Ana Maria Gómez Caravaca
Received: 13 November 2015 / Revised: 8 December 2015 / Accepted: 9 December 2015 / Published: 17 December 2015
(This article belongs to the Special Issue Advances in Molecular Research of Functional and Nutraceutical Food)
View Full-Text   |   Download PDF [2015 KB, uploaded 17 December 2015]

Abstract

This review analyzes current studies of the therapeutic effects of Phoenix dactylifera, or date palm fruit, on the physiologic system. Specifically, we sought to summarize the effects of its application in preventing cell damage, improving cancer therapeutics and reducing damage caused by conventional chemotherapy. Phoenix dactylifera exhibits potent anti-oxidative properties both in vitro and in vivo. This allows the fruit to prevent depletion of intrinsic protection from oxidative cell damage and assist these defense systems in reducing cell damage. Macroscopically, this mechanism may be relevant to the prevention of various adverse drug events common to chemotherapy including hepatotoxicity, nephrotoxicity, gastrotoxicity, and peripheral neuropathy. While such effects have only been studied in small animal systems, research suggests a potential application to more complex mammalian systems and perhaps a solution to some problems of chemotherapy in hepato-compromised and nephro-compromised patients. View Full-Text
Keywords: chemotherapy-induced adverse events; hepatotoxicity; mucositis; nephrotoxicity; peripheral neuropathy chemotherapy-induced adverse events; hepatotoxicity; mucositis; nephrotoxicity; peripheral neuropathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yasin, B.R.; El-Fawal, H.A.N.; Mousa, S.A. Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond. Int. J. Mol. Sci. 2015, 16, 30075-30090.

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