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Int. J. Mol. Sci. 2015, 16(11), 27912-27920; doi:10.3390/ijms161126072

The kin17 Protein in Murine Melanoma Cells

1
Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, 87020-900 Maringá, Paraná, Brazil
2
Laboratório de Imunobiologia do Câncer, Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04023-062 São Paulo, São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Received: 9 September 2015 / Revised: 28 October 2015 / Accepted: 2 November 2015 / Published: 24 November 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2117 KB, uploaded 24 November 2015]   |  

Abstract

kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line B16F10-Nex2 and in two derived subclones with different metastatic potential, B16-8HR and B16-10CR. Nuclear and chromatin-associated protein fractions were analyzed, and kin17 was detected in all fractions, with an elevated concentration observed in the chromatin-associated fraction of the clone with low metastatic potential, suggesting that the kin17 expression level could be a marker of melanoma. View Full-Text
Keywords: kin17 protein; melanoma cells; DNA metabolism kin17 protein; melanoma cells; DNA metabolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ramos, A.C.; Gaspar, V.P.; Kelmer, S.M.G.; Sellani, T.A.; Batista, A.G.U.; De Lima Neto, Q.A.; Rodrigues, E.G.; Fernandez, M.A. The kin17 Protein in Murine Melanoma Cells. Int. J. Mol. Sci. 2015, 16, 27912-27920.

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