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Int. J. Mol. Sci. 2015, 16(11), 27677-27706; doi:10.3390/ijms161126056

Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine

Institute of Pharmacy, Pharmaceutical Technology, Leipzig University, Eilenburger Str. 15a, D-04317 Leipzig, Germany
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Academic Editor: Aaron Tan
Received: 9 October 2015 / Revised: 31 October 2015 / Accepted: 4 November 2015 / Published: 19 November 2015
(This article belongs to the Special Issue Artificial Organs)
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Abstract

Contemporary biomaterials are expected to provide tailored mechanical, biological and structural cues to encapsulated or invading cells in regenerative applications. In addition, the degradative properties of the material also have to be adjustable to the desired application. Oligo- or polymeric building blocks that can be further cross-linked into hydrogel networks, here addressed as macromers, appear as the prime option to assemble gels with the necessary degrees of freedom in the adjustment of the mentioned key parameters. Recent developments in the design of multi-functional macromers with two or more chemically different types of functionalities are summarized and discussed in this review illustrating recent trends in the development of advanced hydrogel building blocks for regenerative applications. View Full-Text
Keywords: functional groups; chemical cross-linking; physical gelation; macromer; macromonomer; smart hydrogel; N-isopropylacrylamide; copolymer; click chemistry functional groups; chemical cross-linking; physical gelation; macromer; macromonomer; smart hydrogel; N-isopropylacrylamide; copolymer; click chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hacker, M.C.; Nawaz, H.A. Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. Int. J. Mol. Sci. 2015, 16, 27677-27706.

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