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Int. J. Mol. Sci. 2015, 16(11), 27378-27390; doi:10.3390/ijms161126032

Serum Biomarkers of (Anti)Oxidant Status for Epidemiological Studies

1
Centre for Health Protection, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
2
Faculty of Medical Sciences, Goce Delcev University, 2000 Stip, Macedonia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Guido R. M. M. Haenen
Received: 19 September 2015 / Revised: 30 October 2015 / Accepted: 2 November 2015 / Published: 16 November 2015
(This article belongs to the Special Issue Antioxidant 2.0——Redox Modulation by Food and Drugs)
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Abstract

In this review, we disclose a selection of serum/plasma biomarkers of (anti)oxidant status related to nutrition, which can be used for measurements in large-scale epidemiological studies. From personal experience, we have come to the following proposal of a set of biomarkers for nutritional intake, (anti)oxidant status, and redox status. We have selected the individual antioxidant vitamins E and A, and the carotenoids which can be measured in large series by HPLC. In addition, vitamin C was selected, which can be measured by an auto-analyzer or HPLC. As a biomarker for oxidative stress, the ROM assay (reactive oxygen metabolites) was selected; for the redox status, the total thiol assay; and for the total antioxidant status the BAP assay (biological antioxidant potential). All of these biomarkers can be measured in large quantities by an auto-analyzer. Critical points in biomarker validation with respect to blood sampling, storage conditions, and measurements are discussed. With the selected biomarkers, a good set is presented for use in the risk assessment between nutrition and (chronic) diseases in large-scale epidemiological studies. Examples of the successful application of these biomarkers in large international studies are presented. View Full-Text
Keywords: biomarkers; nutrition; vitamins; oxidative stress; antioxidant status; redox status; epidemiology biomarkers; nutrition; vitamins; oxidative stress; antioxidant status; redox status; epidemiology
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Jansen, E.; Ruskovska, T. Serum Biomarkers of (Anti)Oxidant Status for Epidemiological Studies. Int. J. Mol. Sci. 2015, 16, 27378-27390.

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