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Int. J. Mol. Sci. 2015, 16(11), 26687-26705; doi:10.3390/ijms161125973

Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach

1
Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology,Via Giuseppe Moruzzi 1, Pisa 56124, Italy
2
Fondazione Toscana Gabriele Monasterio, Via Giuseppe Moruzzi 1, Pisa 56124, Italy
3
Department of Clinical and Experimental Medicine, University of Pisa, Via Volta Pisa 56124, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Jaime M. Ross and Giuseppe Coppotelli
Received: 22 May 2015 / Revised: 13 October 2015 / Accepted: 26 October 2015 / Published: 6 November 2015
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases)
View Full-Text   |   Download PDF [1847 KB, uploaded 6 November 2015]   |  

Abstract

Mitochondria are major determinants of cell fate in ischemia/reperfusion injury (IR) and common effectors of cardio-protective strategies in cardiac ischemic disease. Thyroid hormone homeostasis critically affects mitochondrial function and energy production. Since a low T3 state (LT3S) is frequently observed in the post infarction setting, the study was aimed to investigate the relationship between 72 h post IR T3 levels and both the cardiac function and the mitochondrial proteome in a rat model of IR. The low T3 group exhibits the most compromised cardiac performance along with the worst mitochondrial activity. Accordingly, our results show a different remodeling of the mitochondrial proteome in the presence or absence of a LT3S, with alterations in groups of proteins that play a key role in energy metabolism, quality control and regulation of cell death pathways. Overall, our findings highlight a relationship between LT3S in the early post IR and poor cardiac and mitochondrial outcomes, and suggest a potential implication of thyroid hormone in the cardio-protection and tissue remodeling in ischemic disease. View Full-Text
Keywords: low T3 state; ischemia/reperfusion; mitochondrial function; mitochondria proteomic profiling low T3 state; ischemia/reperfusion; mitochondrial function; mitochondria proteomic profiling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Forini, F.; Ucciferri, N.; Kusmic, C.; Nicolini, G.; Cecchettini, A.; Rocchiccioli, S.; Citti, L.; Iervasi, G. Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach. Int. J. Mol. Sci. 2015, 16, 26687-26705.

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