Next Article in Journal
Genotoxicity of Superparamagnetic Iron Oxide Nanoparticles in Granulosa Cells
Next Article in Special Issue
Metagenomic Analysis of Upwelling-Affected Brazilian Coastal Seawater Reveals Sequence Domains of Type I PKS and Modular NRPS
Previous Article in Journal
Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells
Previous Article in Special Issue
Intra-Genomic Internal Transcribed Spacer Region Sequence Heterogeneity and Molecular Diagnosis in Clinical Microbiology
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(11), 26263-26279; doi:10.3390/ijms161125957

Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome

1
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
2
Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, China
3
Centre for Microbial Genomics and Proteomics, The Chinese University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick C. Y. Woo
Received: 11 July 2015 / Revised: 10 October 2015 / Accepted: 26 October 2015 / Published: 3 November 2015
(This article belongs to the Special Issue Microbial Genomics and Metabolomics)
View Full-Text   |   Download PDF [709 KB, uploaded 3 November 2015]   |  

Abstract

Microbes have co-evolved with human beings for millions of years. They play a very important role in maintaining the health of the host. With the advancement in next generation sequencing technology, the microbiome profiling in the host can be obtained under different circumstances. This review focuses on the current knowledge of the alteration of complex microbial communities upon the infection of different pathogens, such as human immunodeficiency virus, hepatitis B virus, influenza virus, and Mycobacterium tuberculosis, at different body sites. It is believed that the increased understanding of the correlation between infectious disease and the alteration of the microbiome can contribute to better management of disease progression in the future. However, future studies may need to be more integrative so as to establish the exact causality of diseases by analyzing the correlation between microorganisms within the human host and the pathogenesis of infectious diseases. View Full-Text
Keywords: microbiome; metagenomics; next generation sequencing; infectious disease; HIV; HBV; influenza; tuberculosis microbiome; metagenomics; next generation sequencing; infectious disease; HIV; HBV; influenza; tuberculosis
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, Y.; Lun, C.-Y.; Tsui, S.K.-W. Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome. Int. J. Mol. Sci. 2015, 16, 26263-26279.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top