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Int. J. Mol. Sci. 2015, 16(10), 25881-25896; doi:10.3390/ijms161025881

Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression

1
Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
2
Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan
3
School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan
4
Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan
5
Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan
6
Department of Nursing, Mei Ho University, Pingtung 91201, Taiwan
7
Research and Development Department, GenMont Biotech Incorporation, Tainan 74144, Taiwan
8
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
9
Department of Biotechnology, Bharathiar University, Coimbatore 641046, India
10
Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan
11
Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Charles Brennan
Received: 14 August 2015 / Revised: 16 October 2015 / Accepted: 22 October 2015 / Published: 28 October 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [5964 KB, uploaded 28 October 2015]   |  

Abstract

Obesity is one of the major risk factors for nonalcoholic fatty liver disease (NAFLD), and NAFLD is highly associated with an increased risk of cardiovascular disease (CVD). Scholars have suggested that certain probiotics may significantly impact cardiovascular health, particularly certain Lactobacillus species, such as Lactobacillus reuteri GMNL-263 (Lr263) probiotics, which have been shown to reduce obesity and arteriosclerosis in vivo. In the present study, we examined the potential of heat-killed bacteria to attenuate high fat diet (HFD)-induced hepatic and cardiac damages and the possible underlying mechanism of the positive effects of heat-killed Lr263 oral supplements. Heat-killed Lr263 treatments (625 and 3125 mg/kg-hamster/day) were provided as a daily supplement by oral gavage to HFD-fed hamsters for eight weeks. The results show that heat-killed Lr263 treatments reduce fatty liver syndrome. Moreover, heat-killed Lactobacillus reuteri GMNL-263 supplementation in HFD hamsters also reduced fibrosis in the liver and heart by reducing transforming growth factor β (TGF-β) expression levels. In conclusion, heat-killed Lr263 can reduce lipid metabolic stress in HFD hamsters and decrease the risk of fatty liver and cardiovascular disease. View Full-Text
Keywords: Lactobacillus reuteri GMNL-263; transforming growth factor β; cardiovascular diseases Lactobacillus reuteri GMNL-263; transforming growth factor β; cardiovascular diseases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ting, W.-J.; Kuo, W.-W.; Hsieh, D.J.-Y.; Yeh, Y.-L.; Day, C.-H.; Chen, Y.-H.; Chen, R.-J.; Padma, V.V.; Chen, Y.-H.; Huang, C.-Y. Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression. Int. J. Mol. Sci. 2015, 16, 25881-25896.

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