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Int. J. Mol. Sci. 2015, 16(10), 25536-25551; doi:10.3390/ijms161025536

Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy

Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China
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Author to whom correspondence should be addressed.
Academic Editor: Charles J. Malemud
Received: 28 August 2015 / Revised: 7 October 2015 / Accepted: 19 October 2015 / Published: 23 October 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1106 KB, uploaded 23 October 2015]   |  

Abstract

Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like LKB1/AMPK, PI3K/AKT/mTOR, and altering the levels of effective components, such as the Bcl-2 family, Atg and p62. On the other hand, hypoxia-induced autophagy can serve as a mechanism to turn over nutrients, so as to mitigate the adverse condition and then avoid cell death potentially. Due to the effective role of hypoxia, this review focuses on the crosstalk in cell death under hypoxia in tumor progression. Additionally, the illumination of cell death in hypoxia could shed light on the clinical applications of cell death targeted therapy. View Full-Text
Keywords: hypoxia; tumor; autophagy; apoptosis; programmed cell death hypoxia; tumor; autophagy; apoptosis; programmed cell death
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Qiu, Y.; Li, P.; Ji, C. Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy. Int. J. Mol. Sci. 2015, 16, 25536-25551.

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