Next Article in Journal
Excited States and Photodebromination of Selected Polybrominated Diphenyl Ethers: Computational and Quantitative Structure—Property Relationship Studies
Next Article in Special Issue
The Association of ADORA2A and ADORA2B Polymorphisms with the Risk and Severity of Chronic Heart Failure: A Case-Control Study of a Northern Chinese Population
Previous Article in Journal
Pulicaria glutinosa Extract: A Toolbox to Synthesize Highly Reduced Graphene Oxide-Silver Nanocomposites
Previous Article in Special Issue
Cloud Computing-Based TagSNP Selection Algorithm for Human Genome Data
Article Menu
Issue 1 (January) cover image

Export Article

Correction published on 1 April 2015, see Int. J. Mol. Sci. 2015, 16(4), 7375-7376.

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(1), 1143-1159; doi:10.3390/ijms16011143

Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease

1
Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary
2
Department of Cardiology, Faculty of Medicine, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary
3
Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary
4
Vascular Biology, Thrombosis and Hemostasis Research Group of the Hungarian Academy of Sciences, University of Debrecen, 98 Nagyerdei Krt., Debrecen H-4032, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 8 November 2014 / Accepted: 26 December 2014 / Published: 6 January 2015
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
View Full-Text   |   Download PDF [800 KB, uploaded 7 April 2015]   |  

Abstract

The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels. View Full-Text
Keywords: factor XIII (FXIII); factor XIII B subunit (FXIII-B); polymorphism; coronary artery disease; fibrinogen; myocardial infarction; risk assessment factor XIII (FXIII); factor XIII B subunit (FXIII-B); polymorphism; coronary artery disease; fibrinogen; myocardial infarction; risk assessment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mezei, Z.A.; Bereczky, Z.; Katona, É.; Gindele, R.; Balogh, E.; Fiatal, S.; Balogh, L.; Czuriga, I.; Ádány, R.; Édes, I.; Muszbek, L. Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease. Int. J. Mol. Sci. 2015, 16, 1143-1159.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top