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Int. J. Mol. Sci. 2014, 15(9), 16760-16771; https://doi.org/10.3390/ijms150916760

Two New Quinochalcone C-Glycosides from the Florets of Carthamus tinctorius

1,2,3
,
1,2,3,* , 1,2,3
,
1,2,3
,
1,2,3
and
1,2,3
1
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Received: 17 August 2014 / Revised: 1 September 2014 / Accepted: 4 September 2014 / Published: 22 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Two new quinochalcone C-glycosides, named hydroxysafflor yellow B (1) and hydroxysafflor yellow C (2), along with two known quinochalcone C-glycosides, safflomin C (3) and saffloquinoside C (4), and one known flavanone, (2R)-4',5-dihydroxyl-6, 7-di-O-β-d-glucopyranosyl flavanone (5), were isolated from the florets of Carthamus tinctorius. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these quinochalcone C-glycosides together with hydroxysafflor yellow A and anhydrosafflor yellow B were evaluated for their anti-oxidative effects against H2O2-induced cytotoxicity in cultured H9c2 cells. Among them, compound 2 exhibited significant anti-oxidative effects. View Full-Text
Keywords: Carthamus tinctorius; Hong hua; quinochalcone C-glycosides; hydroxysafflor yellow B; hydroxysafflor yellow C; anti-oxidative activity Carthamus tinctorius; Hong hua; quinochalcone C-glycosides; hydroxysafflor yellow B; hydroxysafflor yellow C; anti-oxidative activity
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Yue, S.; Tang, Y.; Xu, C.; Li, S.; Zhu, Y.; Duan, J.-A. Two New Quinochalcone C-Glycosides from the Florets of Carthamus tinctorius. Int. J. Mol. Sci. 2014, 15, 16760-16771.

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