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Int. J. Mol. Sci. 2014, 15(9), 16302-16319; doi:10.3390/ijms150916302

Extraction, Preliminary Characterization and Evaluation of in Vitro Antitumor and Antioxidant Activities of Polysaccharides from Mentha piperita

1
Biology Institute of Shandong Academy of Sciences/Key Laboratory for Applied Microbiology of Shandong Province, Jinan 250014, China
2
State Key Laboratory of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China
3
Fengxian Hospital Affiliated to Southern Medical University, 6600 NanFeng Road, Shanghai 201499, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 26 May 2014 / Revised: 25 August 2014 / Accepted: 3 September 2014 / Published: 15 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

This study describes the extraction, preliminary characterization and evaluation of the in vitro antitumor and antioxidant activities of polysaccharides extracted from Mentha piperita (MPP). The optimal parameters for the extraction of MPP were obtained by Box-Behnken experimental design and response surface methodology (RSM) at the ratio of water to raw material of 20, extraction time of 1.5 h and extraction temperature at 80 °C. Chemical composition analysis showed that MPP was mainly composed of glucuronic acid, galacturonic acid, glucose, galactose and arabinose, and the molecular weight of its two major fractions were estimated to be about 2.843 and 1.139 kDa, respectively. In vitro bioactivity experiments showed that MPP not only inhibited the growth of A549 cells but possessed potent inhibitory action against DNA topoisomerase I (topo I), and an appreciative antioxidant action as well. These results indicate that MPP may be useful for developing safe natural health products. View Full-Text
Keywords: Mentha piperita; response surface methodology; polysaccharide; antitumor; antioxidant Mentha piperita; response surface methodology; polysaccharide; antitumor; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liu, X.; Sun, Z.-L.; Jia, A.-R.; Shi, Y.-P.; Li, R.-H.; Yang, P.-M. Extraction, Preliminary Characterization and Evaluation of in Vitro Antitumor and Antioxidant Activities of Polysaccharides from Mentha piperita. Int. J. Mol. Sci. 2014, 15, 16302-16319.

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