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Int. J. Mol. Sci. 2014, 15(9), 16257-16269; doi:10.3390/ijms150916257

FOXO1, TGF-β Regulation and Wound Healing

1
School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Department of Stomatology, the 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China
3
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Received: 7 April 2014 / Revised: 13 August 2014 / Accepted: 14 August 2014 / Published: 15 September 2014
(This article belongs to the Special Issue Signal Transduction of Tissue Repair)
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Abstract

Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of wound healing. In particular, FOXO1 has significant effects through regulation of transforming growth factor-beta (TGF-β) expression and protecting keratinocytes from oxidative stress. In the absence of FOXO1, there is increased oxidative damage, reduced TGF-β1 expression, reduced migration and proliferation of keratinocytes and increased keratinocytes apoptosis leading to impaired re-epithelialization of wounds. View Full-Text
Keywords: cell death; epithelial; FOXO; transforming growth factor-beta; migration; proliferation; repair; ROS; skin; wound cell death; epithelial; FOXO; transforming growth factor-beta; migration; proliferation; repair; ROS; skin; wound
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hameedaldeen, A.; Liu, J.; Batres, A.; Graves, G.S.; Graves, D.T. FOXO1, TGF-β Regulation and Wound Healing. Int. J. Mol. Sci. 2014, 15, 16257-16269.

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