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Int. J. Mol. Sci. 2014, 15(9), 16100-16113; doi:10.3390/ijms150916100

Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction

1
Molecular Biology Laboratory of Andrology Center, Peking University First Hospital, Peking University, Beijing 100034, China
2
Department of Urology, First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China
*
Author to whom correspondence should be addressed.
Received: 13 August 2014 / Revised: 30 August 2014 / Accepted: 3 September 2014 / Published: 11 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The aim of this study was to investigate the effects of IcarisideII(ICAII) on the prevention of streptozotocin (STZ) induced spermatogenic dysfunction. Forty male Sprague-Dawley rats received intraperitoneal injection of STZ (55 mg/kg) and were equally randomized to gavage feeding of vehicle (the vehicle group) or ICAII (0.5, 1.5 or 4.5 mg/kg/day, respectively). Ten normal rats received vehicle and served as control. Four weeks later, sperm parameters, histopathological changes, testicular lipid peroxidation, antioxidant enzyme activities, and apoptosis index (AI) were evaluated. Results showed that ICAII treatment resulted in a significant recovery of sperm parameters and histopathological changes relative to the vehicle group (p < 0.05). In the vehicle group, antioxidant enzyme activities and the expression of Sertoli cell Vimentin filaments obviously decreased, while lipid peroxidation and AI significantly increased as compared with the control group (p < 0.05). Following ICAII treatment, corrective effects on these items towards normal levels were observed. The results suggested that ICAII has beneficial effect on the preservation of spermatogenic function in the STZ-induced diabetic rats. The mechanisms might be related to its improvement of antioxidant enzyme activities, preservation of the protein expression and apical extensions of Vimentin filaments, and anti-apoptosis capability. View Full-Text
Keywords: streptozotocin; spermatogenic dysfunction; IcarisideII; oxidative stress; diabetes mellitus streptozotocin; spermatogenic dysfunction; IcarisideII; oxidative stress; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xu, Y.; Lei, H.; Guan, R.; Gao, Z.; Li, H.; Wang, L.; Hui, Y.; Zhou, F.; Xin, Z. Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction. Int. J. Mol. Sci. 2014, 15, 16100-16113.

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