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Int. J. Mol. Sci. 2014, 15(9), 14984-14996; doi:10.3390/ijms150914984

Polymer-Immobilized Photosensitizers for Continuous Eradication of Bacteria

Department of Chemical Engineering, Biotechnology and Materials, Ariel University, Ariel 40700, Israel
These authors contributed equally to this work.
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Received: 30 July 2014 / Revised: 14 August 2014 / Accepted: 19 August 2014 / Published: 25 August 2014
(This article belongs to the Special Issue Antimicrobial Polymers)
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Abstract

The photosensitizers Rose Bengal (RB) and methylene blue (MB), when immobilized in polystyrene, were found to exhibit high antibacterial activity in a continuous regime. The photosensitizers were immobilized by dissolution in chloroform, together with polystyrene, with further evaporation of the solvent, yielding thin polymeric films. Shallow reservoirs, bottom-covered with these films, were used for constructing continuous-flow photoreactors for the eradication of Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and wastewater bacteria under illumination with visible white light using a luminescent lamp at a 1.8 mW·cm−2 fluence rate. The bacterial concentration decreased by two to five orders of magnitude in separate reactors with either immobilized RB or MB, as well as in three reactors connected in series, which contained one of the photosensitizers. Bacterial eradication reached more than five orders of magnitude in two reactors connected in series, where the first reactor contained immobilized RB and the second contained immobilized MB. View Full-Text
Keywords: photodynamic antimicrobial chemotherapy; immobilization; photosensitizers; Rose Bengal; methylene blue; polystyrene; antibacterial activity photodynamic antimicrobial chemotherapy; immobilization; photosensitizers; Rose Bengal; methylene blue; polystyrene; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Valkov, A.; Nakonechny, F.; Nisnevitch, M. Polymer-Immobilized Photosensitizers for Continuous Eradication of Bacteria. Int. J. Mol. Sci. 2014, 15, 14984-14996.

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