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Int. J. Mol. Sci. 2014, 15(8), 13299-13316; https://doi.org/10.3390/ijms150813299

Comparative Evaluation of Urinary PCA3 and TMPRSS2: ERG Scores and Serum PHI in Predicting Prostate Cancer Aggressiveness

1
Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France
2
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France
3
Department of Urology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France
4
Institute of Functional Genomics of Lyon, CNRS UMR5242, Lyon 1 University-CNRS-INRA, 46 Allée d'Italie, 69364 Lyon, France
5
Department of Urology, E. Herriot Hospital, Hospices Civils of Lyon, Place d'Arsonval, 69003 Lyon, France
6
Joint Research Unit INSERM 1033, Lyon 1 University, Avenue Rockefeller, 69373 Lyon, France
7
Department of Pathology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France
8
Centre de Recherche en Cancérologie de Lyon, U1052 INSERM, UMR CNRS 5286, Université Lyon I, Centre Léon Bérard, Rue Laennec, 69008 Lyon, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 15 July 2014 / Accepted: 18 July 2014 / Published: 30 July 2014
(This article belongs to the Special Issue Molecular Research in Urology 2014)
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Abstract

It has been suggested that urinary PCA3 and TMPRSS2:ERG fusion tests and serum PHI correlate to cancer aggressiveness-related pathological criteria at prostatectomy. To evaluate and compare their ability in predicting prostate cancer aggressiveness, PHI and urinary PCA3 and TMPRSS2:ERG (T2) scores were assessed in 154 patients who underwent radical prostatectomy for biopsy-proven prostate cancer. Univariate and multivariate analyses using logistic regression and decision curve analyses were performed. All three markers were predictors of a tumor volume ≥0.5 mL. Only PHI predicted Gleason score ≥7. T2 score and PHI were both independent predictors of extracapsular extension (≥pT3), while multifocality was only predicted by PCA3 score. Moreover, when compared to a base model (age, digital rectal examination, serum PSA, and Gleason sum at biopsy), the addition of both PCA3 score and PHI to the base model induced a significant increase (+12%) when predicting tumor volume >0.5 mL. PHI and urinary PCA3 and T2 scores can be considered as complementary predictors of cancer aggressiveness at prostatectomy. View Full-Text
Keywords: urine biomarker; prostate cancer; PCA3; TMPRSS2-ERG gene fusion; PHI; radical prostatectomy; aggressiveness urine biomarker; prostate cancer; PCA3; TMPRSS2-ERG gene fusion; PHI; radical prostatectomy; aggressiveness
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Tallon, L.; Luangphakdy, D.; Ruffion, A.; Colombel, M.; Devonec, M.; Champetier, D.; Paparel, P.; Decaussin-Petrucci, M.; Perrin, P.; Vlaeminck-Guillem, V. Comparative Evaluation of Urinary PCA3 and TMPRSS2: ERG Scores and Serum PHI in Predicting Prostate Cancer Aggressiveness. Int. J. Mol. Sci. 2014, 15, 13299-13316.

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