Next Article in Journal
TCF2 Attenuates FFA-Induced Damage in Islet β-Cells by Regulating Production of Insulin and ROS
Next Article in Special Issue
Molecular Research in Urology 2014: Update on PET/MR Imaging of the Prostate
Previous Article in Journal
Bioinformatics Study of Cancer-Related Mutations within p53 Phosphorylation Site Motifs
Previous Article in Special Issue
Potential Spermatogenesis Recovery with Bone Marrow Mesenchymal Stem Cells in an Azoospermic Rat Model
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(8), 13299-13316; doi:10.3390/ijms150813299

Comparative Evaluation of Urinary PCA3 and TMPRSS2: ERG Scores and Serum PHI in Predicting Prostate Cancer Aggressiveness

1
Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France
2
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France
3
Department of Urology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France
4
Institute of Functional Genomics of Lyon, CNRS UMR5242, Lyon 1 University-CNRS-INRA, 46 Allée d'Italie, 69364 Lyon, France
5
Department of Urology, E. Herriot Hospital, Hospices Civils of Lyon, Place d'Arsonval, 69003 Lyon, France
6
Joint Research Unit INSERM 1033, Lyon 1 University, Avenue Rockefeller, 69373 Lyon, France
7
Department of Pathology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France
8
Centre de Recherche en Cancérologie de Lyon, U1052 INSERM, UMR CNRS 5286, Université Lyon I, Centre Léon Bérard, Rue Laennec, 69008 Lyon, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 20 June 2014 / Revised: 15 July 2014 / Accepted: 18 July 2014 / Published: 30 July 2014
(This article belongs to the Special Issue Molecular Research in Urology 2014)
View Full-Text   |   Download PDF [731 KB, uploaded 30 July 2014]   |  

Abstract

It has been suggested that urinary PCA3 and TMPRSS2:ERG fusion tests and serum PHI correlate to cancer aggressiveness-related pathological criteria at prostatectomy. To evaluate and compare their ability in predicting prostate cancer aggressiveness, PHI and urinary PCA3 and TMPRSS2:ERG (T2) scores were assessed in 154 patients who underwent radical prostatectomy for biopsy-proven prostate cancer. Univariate and multivariate analyses using logistic regression and decision curve analyses were performed. All three markers were predictors of a tumor volume ≥0.5 mL. Only PHI predicted Gleason score ≥7. T2 score and PHI were both independent predictors of extracapsular extension (≥pT3), while multifocality was only predicted by PCA3 score. Moreover, when compared to a base model (age, digital rectal examination, serum PSA, and Gleason sum at biopsy), the addition of both PCA3 score and PHI to the base model induced a significant increase (+12%) when predicting tumor volume >0.5 mL. PHI and urinary PCA3 and T2 scores can be considered as complementary predictors of cancer aggressiveness at prostatectomy. View Full-Text
Keywords: urine biomarker; prostate cancer; PCA3; TMPRSS2-ERG gene fusion; PHI; radical prostatectomy; aggressiveness urine biomarker; prostate cancer; PCA3; TMPRSS2-ERG gene fusion; PHI; radical prostatectomy; aggressiveness
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tallon, L.; Luangphakdy, D.; Ruffion, A.; Colombel, M.; Devonec, M.; Champetier, D.; Paparel, P.; Decaussin-Petrucci, M.; Perrin, P.; Vlaeminck-Guillem, V. Comparative Evaluation of Urinary PCA3 and TMPRSS2: ERG Scores and Serum PHI in Predicting Prostate Cancer Aggressiveness. Int. J. Mol. Sci. 2014, 15, 13299-13316.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top