Effects of Antidepressants on IP-10 Production in LPS-Activated THP-1 Human Monocytes
Abstract
:1. Introduction
2. Results and Discussion
2.1. Results
2.1.1. S-Fluoxetine Suppressed Lipopolysaccharide (LPS)-Induced Interferon-γ-Inducible Protein 10 (IP-10) Expression in THP-1 Cells
2.1.2. R-Fluoxetine also Suppressed LPS-Induced IP-10 Expression in THP-1 Cells
2.1.3. Bupropion Suppressed LPS-Induced IP-10 Expression in THP-1 Cells
2.1.4. Imipramine, Moclobemide, Venlafaxine and Mirtazapine Had no Effect on LPS-Induced IP-10 Expression in THP-1 Cells
2.1.5. Fluoxetine and Bupropion Had no Cytotoxic Effect on THP-1 Cells
2.1.6. S- and R-Fluoxetine Suppressed LPS-Induced IP-10 via the Mitogen-Activated Protein Kinase (MAPK)-p38 Pathway
2.2. Discussion
3. Experimental Section
3.1. Reagents and Cell Preparation
3.2. Cell Viability Tests
3.3. Western Blotting Analysis
3.4. Enzyme-Linked Immunosorbent Assay (ELISA)
3.5. Statistical Analysis
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Tsai, J.-H.; Kuo, C.-H.; Yang, P.; Cheng, K.-H.; Wang, P.-W.; Chen, C.-C.; Hung, C.-H. Effects of Antidepressants on IP-10 Production in LPS-Activated THP-1 Human Monocytes. Int. J. Mol. Sci. 2014, 15, 13223-13235. https://doi.org/10.3390/ijms150813223
Tsai J-H, Kuo C-H, Yang P, Cheng K-H, Wang P-W, Chen C-C, Hung C-H. Effects of Antidepressants on IP-10 Production in LPS-Activated THP-1 Human Monocytes. International Journal of Molecular Sciences. 2014; 15(8):13223-13235. https://doi.org/10.3390/ijms150813223
Chicago/Turabian StyleTsai, Jui-Hsiu, Chang-Hung Kuo, Pinchen Yang, Kuang-Hung Cheng, Peng-Wei Wang, Cheng-Chung Chen, and Chih-Hsing Hung. 2014. "Effects of Antidepressants on IP-10 Production in LPS-Activated THP-1 Human Monocytes" International Journal of Molecular Sciences 15, no. 8: 13223-13235. https://doi.org/10.3390/ijms150813223