Next Article in Journal
Identifying the Subfamilies of Voltage-Gated Potassium Channels Using Feature Selection Technique
Previous Article in Journal
Rapid Adsorption of Heavy Metals by Fe3O4/Talc Nanocomposite and Optimization Study Using Response Surface Methodology
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(7), 12928-12939; doi:10.3390/ijms150712928

WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells

1
State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
2
Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China
3
Department of Medical Oncology, the Fifth People's Hospital of Chengdu, Chengdu 611130, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 16 May 2014 / Revised: 4 July 2014 / Accepted: 14 July 2014 / Published: 21 July 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [1485 KB, uploaded 21 July 2014]   |  

Abstract

Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of β-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment. View Full-Text
Keywords: WNT16B; fibroblasts; regulatory T cells; dendritic cells; microenvironment WNT16B; fibroblasts; regulatory T cells; dendritic cells; microenvironment
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shen, C.-C.; Kang, Y.-H.; Zhao, M.; He, Y.; Cui, D.-D.; Fu, Y.-Y.; Yang, L.-L.; Gou, L.-T. WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells. Int. J. Mol. Sci. 2014, 15, 12928-12939.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top