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Int. J. Mol. Sci. 2014, 15(7), 12928-12939; doi:10.3390/ijms150712928
Article

WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells

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Received: 16 May 2014 / Revised: 4 July 2014 / Accepted: 14 July 2014 / Published: 21 July 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Treatment for cancer can induce a series of secreted factors into the tumor microenvironment, which can affect cancer progression. Wingless-type MMTV (mouse mammary tumor virus) integration site 16B (WNT16B) is a new member of the WNT family and has been reported to play growth-related roles in previous studies. In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. We also demonstrated that fibroblast-derived WNT16B could result in accumulation of β-catenin in dendritic cells and secretion of interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), which contributed to the differentiation of regulatory T cells in a co-culture environment. These results shed light on the roles of WNT16B in immune regulation, especially in regard to cancer treatment.
Keywords: WNT16B; fibroblasts; regulatory T cells; dendritic cells; microenvironment WNT16B; fibroblasts; regulatory T cells; dendritic cells; microenvironment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shen, C.-C.; Kang, Y.-H.; Zhao, M.; He, Y.; Cui, D.-D.; Fu, Y.-Y.; Yang, L.-L.; Gou, L.-T. WNT16B from Ovarian Fibroblasts Induces Differentiation of Regulatory T Cells through β-Catenin Signal in Dendritic Cells. Int. J. Mol. Sci. 2014, 15, 12928-12939.

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