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Int. J. Mol. Sci. 2014, 15(7), 12495-12506; doi:10.3390/ijms150712495

Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients

1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi 622, Taiwan
3
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 8 May 2014 / Revised: 30 June 2014 / Accepted: 1 July 2014 / Published: 15 July 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Although the genetic polymorphism of Stromal Cell-Derived Factor 1 (SDF-1) is associated with higher mortality of liver allograft recipients, the role of SDF-1 in the modulation of renal allograft outcomes is unclear. Between March 2000 and January 2008, we recruited 252 non-diabetic renal transplant recipients (RTRs). Baseline characteristics and blood chemistry were recorded. Genomic DNA extraction with polymerase chain reaction-restriction fragment length polymorphism was utilized to analyze the genetic polymorphisms of SDF-1 (rs1801157). The influence of SDF-1 on an adverse renal allograft outcome, defined as either a doubling of serum creatinine, graft failure, or patient death was evaluated. Sixteen patients with the SDF-1 AA/AG genotype and nine with the SDF-1 GG genotype reached an adverse outcome. According to Kaplan-Meier analysis, patients carrying the SDF-1 AA/AG genotype or A allele showed a significantly higher risk of reaching an adverse outcome than those carrying the SDF-1 GG genotype or G allele (p = 0.041; p = 0.0051, respectively; log rank test). Stepwise multivariate Cox proportional regression analysis revealed that patients carrying the SDF-1 AA/AG genotype and A allele had a 2.742-fold (95% CI. 1.106–6.799, p = 0.03) and 2.306-fold (95% CI. 1.254–4.24, p = 0.008) risk of experiencing an adverse outcome. The SDF-1 AA/AG genotype and A allele have a detrimental impact on the long-term outcome of RTRs. View Full-Text
Keywords: gene polymorphism; stromal cell-derived factor 1; renal transplantation gene polymorphism; stromal cell-derived factor 1; renal transplantation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, C.-J.; Tsai, J.-P.; Yang, S.-F.; Lian, J.-D.; Chang, H.-R. Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients. Int. J. Mol. Sci. 2014, 15, 12495-12506.

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