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Int. J. Mol. Sci. 2014, 15(7), 12027-12060; doi:10.3390/ijms150712027

Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived from Phytonutrients

1
Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia
2
Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia
3
Faculty of Chemical Engineering, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia
4
Department of Basic Sciences, DHA Suffa University, Off, Khayaban-e-Tufail, Phase VII (Extension), DHA, Karachi 75500, Pakistan
*
Authors to whom correspondence should be addressed.
Received: 22 May 2014 / Revised: 12 June 2014 / Accepted: 26 June 2014 / Published: 7 July 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)

Abstract

Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids. View Full-Text
Keywords: microbial transformation; tetranortriterpenoids; tetracyclic triterpenoids; pentacyclic triterpenoids; biocatalysis microbial transformation; tetranortriterpenoids; tetracyclic triterpenoids; pentacyclic triterpenoids; biocatalysis
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shah, S.A.A.; Tan, H.L.; Sultan, S.; Faridz, M.A.B.M.; Shah, M.A.B.M.; Nurfazilah, S.; Hussain, M. Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived from Phytonutrients. Int. J. Mol. Sci. 2014, 15, 12027-12060.

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