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Int. J. Mol. Sci. 2014, 15(7), 11760-11772; https://doi.org/10.3390/ijms150711760

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

1
Medical Education Center, Kaohsiung Armed Force General Hospital, Kaohsiung 802, Taiwan
2
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
3
Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan
4
Department of Pharmacology, School of Medicine, China Medical University, Taichung 404, Taiwan
5
Department of Orthopedic Surgery, Taichung Hospital, Ministry of Health and Welfare, Taichung 403, Taiwan
6
School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
7
Department of Nursing, National Taichung University of Science and Technology, Taichung 403, Taiwan
8
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan
9
Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan
*
Author to whom correspondence should be addressed.
Received: 16 April 2014 / Revised: 10 June 2014 / Accepted: 13 June 2014 / Published: 2 July 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lactiflora Pallas, exhibits anti-inflammatory and anti-tumor activity; whether paeonol regulates metastatic chondrosarcoma is largely unknown. Here, we find paeonol do not increase apoptosis. By contrast, at non-cytotoxic concentrations, paeonol suppresses migration and invasion of chondrosarcoma cells. We also demonstrate paeonol enhancing miR-141 expression and miR-141 inhibitor reversing paeonol-inhibited cell motility; paeonol also reduces protein kinase C (PKC)d and c-Src kinase activity. Since paeonol inhibits migration and invasion of human chondrosarcoma via up-regulation of miR-141 via PKCd and c-Src pathways, it thus might be a novel anti-metastasis agent for treatment of metastatic chondrosarcoma. View Full-Text
Keywords: paeonol; chondrosarcoma; miR-141; metastasis paeonol; chondrosarcoma; miR-141; metastasis
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Horng, C.-T.; Shieh, P.-C.; Tan, T.-W.; Yang, W.-H.; Tang, C.-H. Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway. Int. J. Mol. Sci. 2014, 15, 11760-11772.

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