Int. J. Mol. Sci. 2014, 15(7), 11626-11636; doi:10.3390/ijms150711626

Immunomodulating Activity of Aronia melanocarpa Polyphenols

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Received: 19 May 2014; in revised form: 18 June 2014 / Accepted: 20 June 2014 / Published: 30 June 2014
(This article belongs to the Special Issue Bioactive Phenolics and Polyphenols)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The immunomodulating effects of isolated proanthocyanidin-rich fractions, procyanidins C1, B5 and B2 and anthocyanins of Aronia melanocarpa were investigated. In this work, the complement-modulating activities, the inhibitory activities on nitric oxide (NO) production in LPS-induced RAW 264.7 macrophages and effects on cell viability of these polyphenols were studied. Several of the proanthocyanidin-rich fractions, the procyanidins C1, B5 and B2 and the cyanidin aglycone possessed strong complement-fixing activities. Cyanidin 3-glucoside possessed stronger activity than the other anthocyanins. Procyanidins C1, B5 and B2 and proanthocyanidin-rich fractions having an average degree of polymerization (PD) of 7 and 34 showed inhibitory activities on NO production in LPS-stimulated RAW 264.7 mouse macrophages. All, except for the fraction containing proanthocyanidins with PD 34, showed inhibitory effects without affecting cell viability. This study suggests that polyphenolic compounds of A. melanocarpa may have beneficial effects as immunomodulators and anti-inflammatory agents.
Keywords: Aronia melanocarpa; anthocyanins; procyanidins; complement system; macrophages; nitric oxide; immunomodulation
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MDPI and ACS Style

Ho, G.T.T.; Bräunlich, M.; Austarheim, I.; Wangensteen, H.; Malterud, K.E.; Slimestad, R.; Barsett, H. Immunomodulating Activity of Aronia melanocarpa Polyphenols. Int. J. Mol. Sci. 2014, 15, 11626-11636.

AMA Style

Ho GTT, Bräunlich M, Austarheim I, Wangensteen H, Malterud KE, Slimestad R, Barsett H. Immunomodulating Activity of Aronia melanocarpa Polyphenols. International Journal of Molecular Sciences. 2014; 15(7):11626-11636.

Chicago/Turabian Style

Ho, Giang T.T.; Bräunlich, Marie; Austarheim, Ingvild; Wangensteen, Helle; Malterud, Karl E.; Slimestad, Rune; Barsett, Hilde. 2014. "Immunomodulating Activity of Aronia melanocarpa Polyphenols." Int. J. Mol. Sci. 15, no. 7: 11626-11636.

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