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Int. J. Mol. Sci. 2014, 15(6), 9566-9578; doi:10.3390/ijms15069566
Article

New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri

1,†
, 2,†
, 3
, 4
, 5
, 6
, 7
 and 2,*
Received: 3 March 2014; in revised form: 7 May 2014 / Accepted: 13 May 2014 / Published: 28 May 2014
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (417). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 412, and 1417 exhibited inhibition (IC50 ≤ 7.31 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 911, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 µg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
Keywords: Cnidium monnieri; umbelliferae; isoflavones; structure elucidation; anti-inflammatory activity Cnidium monnieri; umbelliferae; isoflavones; structure elucidation; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, T.-H.; Chen, Y.-C.; Hwang, T.-L.; Shu, C.-W.; Sung, P.-J.; Lim, Y.-P.; Kuo, W.-L.; Chen, J.-J. New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri. Int. J. Mol. Sci. 2014, 15, 9566-9578.

AMA Style

Lee T-H, Chen Y-C, Hwang T-L, Shu C-W, Sung P-J, Lim Y-P, Kuo W-L, Chen J-J. New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri. International Journal of Molecular Sciences. 2014; 15(6):9566-9578.

Chicago/Turabian Style

Lee, Tzong-Huei; Chen, Yuan-Chih; Hwang, Tsong-Long; Shu, Chih-Wen; Sung, Ping-Jyun; Lim, Yun-Ping; Kuo, Wen-Lung; Chen, Jih-Jung. 2014. "New Coumarins and Anti-Inflammatory Constituents from the Fruits of Cnidium monnieri." Int. J. Mol. Sci. 15, no. 6: 9566-9578.



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