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Int. J. Mol. Sci. 2014, 15(6), 11054-11063; doi:10.3390/ijms150611054
Article

A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients

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Received: 26 May 2014; in revised form: 6 June 2014 / Accepted: 13 June 2014 / Published: 19 June 2014
(This article belongs to the Section Molecular Pathology)
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Abstract: Coronary heart disease (CHD) is highly prevalent globally and a major cause of mortality. Genetic predisposition is a non-modifiable risk factor associated with CHD. Eighty-four Chinese patients with CHD and 253 healthy Chinese controls without CHD were recruited. Major clinical data were collected, and a single nucleotide polymorphism (SNP) in the stromal cell-derived factor 1 (SDF-1) gene at position 801 (G to A, rs1801157) in the 3'-untranslated region was identified. The correlation between rs1801157 genotypes and CHD was evaluated by a multivariate logistic regression analysis. The allele frequency in the CHD and control groups was in Hardy-Weinberg equilibrium (HWE) (p > 0.05). The frequency of the GG genotype in the CHD group (59.5%) was significantly higher than that in the control group (49.8%) (p = 0.036). A number of variables, including male sex, age, presence of hypertension, and the levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), uric acid, and total bilirubin, were associated with CHD in a primary univariate analysis. In a multivariable logistic regression analysis, the GG genotype (GG:AA, odds ratio (OR) = 2.31, 95% confidence interval (CI) = 1.21–5.23), male sex, advanced age (≥60 years), presence of hypertension, LDL-C level ≥ 3.33 mg/dL, HDL-C level < 1.03 mg/dL, and TG level ≥ 1.7 mg/dL were independent risk factors for CHD.
Keywords: single nucleotide polymorphism (SNP); stromal cell-derived factor 1 (SDF-1) gene; coronary heart disease (CHD); Chinese patients single nucleotide polymorphism (SNP); stromal cell-derived factor 1 (SDF-1) gene; coronary heart disease (CHD); Chinese patients
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Feng, L.; Nian, S.-Y.; Hao, Y.-L.; Xu, W.-B.; Ye, D.; Zhang, X.-F.; Li, D.; Zheng, L. A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients. Int. J. Mol. Sci. 2014, 15, 11054-11063.

AMA Style

Feng L, Nian S-Y, Hao Y-L, Xu W-B, Ye D, Zhang X-F, Li D, Zheng L. A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients. International Journal of Molecular Sciences. 2014; 15(6):11054-11063.

Chicago/Turabian Style

Feng, Lei; Nian, Shi-Yan; Hao, Ying-Lu; Xu, Wen-Bo; Ye, Dan; Zhang, Xing-Feng; Li, Dan; Zheng, Lei. 2014. "A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients." Int. J. Mol. Sci. 15, no. 6: 11054-11063.



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