Int. J. Mol. Sci. 2014, 15(6), 10296-10333; doi:10.3390/ijms150610296
Review

Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

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Received: 20 February 2014; in revised form: 23 May 2014 / Accepted: 28 May 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Signal Transduction of Tissue Repair)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinical use in patients with anemia for two and half decades and has facilitated studies of EPO action. Reports of animal and cell models of ischemic stress in vitro and injury suggest potential EPO benefit beyond red blood cell production including vascular endothelial response to increase nitric oxide production, which facilitates oxygen delivery to brain, heart and other non-hematopoietic tissues. This review discusses these and other reports of EPO action beyond red blood cell production, including EPO response affecting metabolism and obesity in animal models. Observations of EPO activity in cell and animal model systems, including mice with tissue specific deletion of EPO receptor (EpoR), suggest the potential for EPO response in metabolism and disease.
Keywords: erythropoietin; erythropoietin receptor; signal transduction; stress response; wound healing; endothelial; brain; cardiovascular; inflammation; metabolism; obesity
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MDPI and ACS Style

Zhang, Y.; Wang, L.; Dey, S.; Alnaeeli, M.; Suresh, S.; Rogers, H.; Teng, R.; Noguchi, C.T. Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism. Int. J. Mol. Sci. 2014, 15, 10296-10333.

AMA Style

Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT. Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism. International Journal of Molecular Sciences. 2014; 15(6):10296-10333.

Chicago/Turabian Style

Zhang, Yuanyuan; Wang, Li; Dey, Soumyadeep; Alnaeeli, Mawadda; Suresh, Sukanya; Rogers, Heather; Teng, Ruifeng; Noguchi, Constance T. 2014. "Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism." Int. J. Mol. Sci. 15, no. 6: 10296-10333.

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