Molecular Characterization of α- and β-Thalassaemia among Malay Patients
AbstractBoth α- and β-thalassaemia syndromes are public health problems in the multi-ethnic population of Malaysia. To molecularly characterise the α- and β-thalassaemia deletions and mutations among Malays from Penang, Gap-PCR and multiplexed amplification refractory mutation systems were used to study 13 α-thalassaemia determinants and 20 β-thalassaemia mutations in 28 and 40 unrelated Malays, respectively. Four α-thalassaemia deletions and mutations were demonstrated. −−SEA deletion and αCSα accounted for more than 70% of the α-thalassaemia alleles. Out of the 20 β-thalassaemia alleles studied, nine different β-thalassaemia mutations were identified of which βE accounted for more than 40%. We concluded that the highest prevalence of (α- and β-thalassaemia alleles in the Malays from Penang are −−SEA deletion and βE mutation, respectively. View Full-Text
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Yatim, N.F.M.; Rahim, M.A.; Menon, K.; Al-Hassan, F.M.; Ahmad, R.; Manocha, A.B.; Saleem, M.; Yahaya, B.H. Molecular Characterization of α- and β-Thalassaemia among Malay Patients. Int. J. Mol. Sci. 2014, 15, 8835-8845.
Yatim NFM, Rahim MA, Menon K, Al-Hassan FM, Ahmad R, Manocha AB, Saleem M, Yahaya BH. Molecular Characterization of α- and β-Thalassaemia among Malay Patients. International Journal of Molecular Sciences. 2014; 15(5):8835-8845.Chicago/Turabian Style
Yatim, Nur F.M.; Rahim, Masitah A.; Menon, Kavitha; Al-Hassan, Faisal M.; Ahmad, Rahimah; Manocha, Anita B.; Saleem, Mohamed; Yahaya, Badrul H. 2014. "Molecular Characterization of α- and β-Thalassaemia among Malay Patients." Int. J. Mol. Sci. 15, no. 5: 8835-8845.