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Int. J. Mol. Sci. 2014, 15(4), 7037-7048; doi:10.3390/ijms15047037

LIM Mineralization Protein-1 Inhibits the Malignant Phenotypes of Human Osteosarcoma Cells

1
Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
2
Department of Orthopedics, the First People's Hospital of Jingdezhen, Jingdezhen 333000, China
3
Department of Children Health and Care, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China
4
Department of Oncology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 4 March 2014 / Accepted: 17 March 2014 / Published: 23 April 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Osteosarcoma (OS), also known as osteogenic sarcoma, is the most common primary malignancy of bone tumor in children and adolescents. However, its underlying molecular pathogenesis is still only vaguely understood. Recently, LIM mineralization protein-1 (LMP-1) was reported to be an essential positive regulator of osteoblast differentiation. In the present study, we found that the expression of LMP-1 is downregulated in OS tissues compared with adjacent normal tissues. Moreover, we restored the expression of LMP-1 through a recombinant adenovirus. Overexpression of LMP-1 inhibited cell proliferation and invasion, arrested cell cycle progression, and induced apoptosis in vitro. Finally, ectopic LMP-1 expression suppressed the expression of Runx2 and BMP-2 in OS cells. These data demonstrate that LMP-1 is an essential tumor suppressor in the OS pathological process, which will provide a new opportunity for discovering and identifying novel effective treatment strategies. View Full-Text
Keywords: LMP-1; osteosarcoma; tumor suppressor gene; Runx2; BMP-2 LMP-1; osteosarcoma; tumor suppressor gene; Runx2; BMP-2
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liu, H.; Huang, L.; Zhang, Z.; Zhang, Z.; Yu, Z.; Chen, X.; Chen, Z.; Zen, Y.; Yang, D.; Han, Z.; Shu, Y.; Dai, M.; Cao, K. LIM Mineralization Protein-1 Inhibits the Malignant Phenotypes of Human Osteosarcoma Cells. Int. J. Mol. Sci. 2014, 15, 7037-7048.

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