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Int. J. Mol. Sci. 2014, 15(4), 6741-6756; doi:10.3390/ijms15046741

Design, Synthesis and Bioactivity of N-Glycosyl-N'-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives

1
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China
2
Division of Nanobiology, Advanced Integrated Science, Chiba University, Matsudo, Chiba 271-0092, Japan
3
Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China
4
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
Received: 6 March 2014 / Revised: 30 March 2014 / Accepted: 10 April 2014 / Published: 21 April 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides d-glucose, d-galactose, d-mannose, d-fucose and d-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by 1H NMR spectroscopy. The results showed that, except for the d-glucose derivatives, which were in the presence of β-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls. View Full-Text
Keywords: glycosylhydrazide; synthesis; tautomer; antifungal activity; antitumor activity glycosylhydrazide; synthesis; tautomer; antifungal activity; antitumor activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cui, Z.; Su, H.; Jiang, J.; Yang, X.; Nishida, Y. Design, Synthesis and Bioactivity of N-Glycosyl-N'-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives. Int. J. Mol. Sci. 2014, 15, 6741-6756.

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