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Int. J. Mol. Sci. 2014, 15(3), 4977-4993; doi:10.3390/ijms15034977
Review

The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia

*  and
Received: 3 February 2014; in revised form: 27 February 2014 / Accepted: 12 March 2014 / Published: 20 March 2014
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Abstract: Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors.
Keywords: resveratrol; non-Hodgkin lymphoma; apoptosis resveratrol; non-Hodgkin lymphoma; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Frazzi, R.; Tigano, M. The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia. Int. J. Mol. Sci. 2014, 15, 4977-4993.

AMA Style

Frazzi R, Tigano M. The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia. International Journal of Molecular Sciences. 2014; 15(3):4977-4993.

Chicago/Turabian Style

Frazzi, Raffaele; Tigano, Marco. 2014. "The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia." Int. J. Mol. Sci. 15, no. 3: 4977-4993.



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