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Int. J. Mol. Sci. 2014, 15(3), 4977-4993; doi:10.3390/ijms15034977

The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia

*  and
Translational Research Laboratory, Department of Research and Statistics, IRCCS Arcispedale S.Maria Nuova, 42123 Reggio Emilia, Italy
* Author to whom correspondence should be addressed.
Received: 3 February 2014 / Revised: 27 February 2014 / Accepted: 12 March 2014 / Published: 20 March 2014
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors.
Keywords: resveratrol; non-Hodgkin lymphoma; apoptosis resveratrol; non-Hodgkin lymphoma; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Frazzi, R.; Tigano, M. The Multiple Mechanisms of Cell Death Triggered by Resveratrol in Lymphoma and Leukemia. Int. J. Mol. Sci. 2014, 15, 4977-4993.

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