Int. J. Mol. Sci. 2014, 15(4), 5304-5322; doi:10.3390/ijms15045304
Article

Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics

1,2email, 1email, 1email, 1email, 1email, 3email, 1email and 1,* email
Received: 14 November 2013; in revised form: 7 February 2014 / Accepted: 14 March 2014 / Published: 26 March 2014
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Abstract: Aerobic interval training (AIT) can favorably affect cardiovascular diseases. However, the effects of AIT on post-myocardial infarction (MI)—associated mitochondrial dysfunctions remain unclear. In this study, we investigated the protective effects of AIT on myocardial mitochondria in post-MI rats by focusing on mitochondrial dynamics (fusion and fission). Mitochondrial respiratory functions (as measured by the respiratory control ratio (RCR) and the ratio of ADP to oxygen consumption (P/O)); complex activities; dynamic proteins (mitofusin (mfn) 1/2, type 1 optic atrophy (OPA1) and dynamin-related protein1 (DRP1)); nuclear peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α); and the oxidative signaling of extracellular signal-regulated kinase (ERK) 1/2, c-Jun NH2-terminal protein kinase (JNK) and P53 were observed. Post-MI rats exhibited mitochondrial dysfunction and adverse mitochondrial network dynamics (reduced fusion and increased fission), which was associated with activated ERK1/2-JNK-P53 signaling and decreased nuclear PGC-1α. After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1α and inactivation of the ERK1/2-JNK-P53 signaling were observed. These data demonstrate that AIT may restore the post-MI mitochondrial function by inhibiting dynamics pathological remodeling, which may be associated with inactivation of ERK1/2-JNK-P53 signaling and increase in nuclear PGC-1α expression.
Keywords: myocardial infarction; mitochondrial dysfunction; fusion; fission; mitochondrial dynamics; aerobic interval training
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jiang, H.-K.; Wang, Y.-H.; Sun, L.; He, X.; Zhao, M.; Feng, Z.-H.; Yu, X.-J.; Zang, W.-J. Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics. Int. J. Mol. Sci. 2014, 15, 5304-5322.

AMA Style

Jiang H-K, Wang Y-H, Sun L, He X, Zhao M, Feng Z-H, Yu X-J, Zang W-J. Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics. International Journal of Molecular Sciences. 2014; 15(4):5304-5322.

Chicago/Turabian Style

Jiang, Hong-Ke; Wang, You-Hua; Sun, Lei; He, Xi; Zhao, Mei; Feng, Zhi-Hui; Yu, Xiao-Jiang; Zang, Wei-Jin. 2014. "Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics." Int. J. Mol. Sci. 15, no. 4: 5304-5322.


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