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Int. J. Mol. Sci. 2014, 15(3), 4608-4618; doi:10.3390/ijms15034608

8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

1
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
2
Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
3
Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan
4
Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
5
Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan
6
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
7
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
8
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
9
Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan
10
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
11
Department of Biotechnology, Asia University, Taichung 413, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 10 December 2013 / Revised: 13 February 2014 / Accepted: 6 March 2014 / Published: 17 March 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl- 2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3'-O-methylvaginol (3), together with seven known compounds (410) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.
Keywords: Chinese herb; Cnidium monnieri; 8-alkylcoumarin; oxidative stress Chinese herb; Cnidium monnieri; 8-alkylcoumarin; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chang, C.-I.; Hu, W.-C.; Shen, C.-P.; Hsu, B.-D.; Lin, W.-Y.; Sung, P.-J.; Wang, W.-H.; Wu, J.-B.; Kuo, Y.-H. 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage. Int. J. Mol. Sci. 2014, 15, 4608-4618.

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