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Int. J. Mol. Sci. 2014, 15(3), 4608-4618; doi:10.3390/ijms15034608
Article

8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

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Received: 10 December 2013 / Revised: 13 February 2014 / Accepted: 6 March 2014 / Published: 17 March 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl- 2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3'-O-methylvaginol (3), together with seven known compounds (410) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.
Keywords: Chinese herb; Cnidium monnieri; 8-alkylcoumarin; oxidative stress Chinese herb; Cnidium monnieri; 8-alkylcoumarin; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chang, C.-I.; Hu, W.-C.; Shen, C.-P.; Hsu, B.-D.; Lin, W.-Y.; Sung, P.-J.; Wang, W.-H.; Wu, J.-B.; Kuo, Y.-H. 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage. Int. J. Mol. Sci. 2014, 15, 4608-4618.

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