Int. J. Mol. Sci. 2014, 15(2), 3287-3298; doi:10.3390/ijms15023287
Article

Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101)

Received: 21 January 2014; in revised form: 11 February 2014 / Accepted: 17 February 2014 / Published: 21 February 2014
(This article belongs to the Section Green Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimental design has been used to develop and optimize a novel microwave-assisted synthesis (MAOS) of the AS101. In comparison to the results observed in the literature, refluxing Te(IV) chloride and ethylene glycol in acetonitrile (Method A), or by refluxing Te(IV) chloride and ammonium chloride in ethylene glycol (Method B), it was found that the developed methods in the present work are an effective alternative, because although performance slightly decreases compared to conventional procedures (75% vs. 79% by Method A, and 45% vs. 51% by Method B), reaction times decreased from 4 h to 30 min and from 4 h to 10 min, by Methods A and B respectively. MAOS is proving to be of value in the rapid synthesis of compounds with new and improved biological activities, specially based on the benefit of its shorter reaction times.
Keywords: Tellurium; AS101; ammonium trichloro[1,2-ethanediolato-O,O']-tellurate; microwave irradiation; antitumoral
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MDPI and ACS Style

Vázquez-Tato, M.P.; Mena-Menéndez, A.; Feás, X.; Seijas, J.A. Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101). Int. J. Mol. Sci. 2014, 15, 3287-3298.

AMA Style

Vázquez-Tato MP, Mena-Menéndez A, Feás X, Seijas JA. Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101). International Journal of Molecular Sciences. 2014; 15(2):3287-3298.

Chicago/Turabian Style

Vázquez-Tato, M. P.; Mena-Menéndez, Alberto; Feás, Xesús; Seijas, Julio A. 2014. "Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101)." Int. J. Mol. Sci. 15, no. 2: 3287-3298.

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